Face processing in Williams Syndrome and autism

Individuals with Williams syndrome (WS) have been characterised as hyper-sociable, showing an extreme compulsion to engage in communication with other people, whilst the opposite has been cited regarding autism. The most important social cue in our environment is the human face, which must be successfully recognised and interpreted for communicative signals. Although clear differences are apparent in social skills, individuals with WS and autism have been described as showing similarly atypical face processing styles. The present research addressed issues of face perception in Williams syndrome and autism to gain further insights into social abilities of individuals with these developmental disorders. Importantly, the research was grounded in typical face perception methods. The investigation began with a large-scale exploration of face skills, probing identity, eye gaze, expressions of emotion and lip reading to ask how these two disorders uniquely impact upon performance. Participants with WS and autism could be dissociated from those with general developmental delay and from each other primarily on the basis of eye gaze ability. Participants with WS showed strong eye gaze abilities whilst participants with autism had extreme difficulties. Although interpretation of expressions of emotion also showed a difference between groups, autism and WS did not uniquely impact upon the processing of identity or lip reading. The exploration also allowed the consideration of models of face perception; characterised by a typical modular structure in WS but a lack of modularity in autism. The second line of inquiry considered identity processing and firstly asked whether participants were more accurate at matching faces from internal or external features. Participants with WS showed an atypical use of internal features for matching unfamiliar faces, which may be linked to an atypical interaction style and exaggerated interest in unfamiliar people. Participants with autism used the same strategy to match faces of familiar and unfamiliar people and hence familiarity did not impact upon processing style. Subsequent chapters probed feature salience (eyes .v. mouth) and structural encoding. Across paradigms typically developing participants and those with WS showed greater accuracy using the eye than mouth region, a pattern not evident in autism. Regarding structural encoding, individuals with WS showed use of configural cues under the task demands implemented in this thesis, where individuals with autism were only able to interpret featural cues. Previous evidence of similar face processing styles in WS and autism were not supported. Taken together the findings provide further insights into face perception and social functioning in WS and autism. The research used the same participants across paradigms, considered level of functioning on the autistic spectrum and included investigations of WS and autism in the same research programme. Additional to the main experimental studies, pilot data is provided to open a new line of investigation into physiological arousal associated with holding eye contact in WS. Therefore, on the basis of the experiments conducted here, a number of suggestions are made to carry the research forward in future investigations. Throughout the thesis as a whole, comparisons are made between individuals with WS and autism that further our understanding of the links between face processing and social expertise.ESRC funde

Anxiety in Williams Syndrome: The role of social behaviour, executive functions and change over time

Anxiety is a prevalent mental health issue for individuals with Williams syndrome (WS). Relatively little is known about the developmental course of anxiety, or how it links with core features of WS, namely social and executive functioning (EF). In this study, parent-reports of anxiety were compared across a 4-year period (N = 17), and links between anxiety, social and EF were explored from concurrent parent-reports (N = 26). Results indicated that high anxiety persisted over time, and anxiety was related to impairments in both social and executive functioning. Importantly, results indicated that impairments in EFs may drive the links between anxiety and social functioning. This timely investigation provides new insights into anxiety in WS and highlights potential areas for intervention

The disentanglement of the neural and experiential complexity of self-generated thoughts : A users guide to combining experience sampling with neuroimaging data

Human cognition is not limited to the processing of events in the external environment, and the covert nature of certain aspects of the stream of consciousness (e.g. experiences such as mind-wandering) provides a methodological challenge. Although research has shown that we spend a substantial amount of time focused on thoughts and feelings that are intrinsically generated, evaluating such internal states, purely on psychological grounds can be restrictive. In this review of the different methods used to examine patterns of ongoing thought, we emphasise how the process of triangulation between neuroimaging techniques, with self-reported information, is important for the development of a more empirically grounded account of ongoing thought. Specifically, we show how imaging techniques have provided critical information regarding the presence of covert states and can help in the attempt to identify different aspects of experience

Face processing in Williams Syndrome and autism

Individuals with Williams syndrome (WS) have been characterised as hyper-sociable, showing an extreme compulsion to engage in communication with other people, whilst the opposite has been cited regarding autism. The most important social cue in our environment is the human face, which must be successfully recognised and interpreted for communicative signals. Although clear differences are apparent in social skills, individuals with WS and autism have been described as showing similarly atypical face processing styles. The present research addressed issues of face perception in Williams syndrome and autism to gain further insights into social abilities of individuals with these developmental disorders. Importantly, the research was grounded in typical face perception methods. The investigation began with a large-scale exploration of face skills, probing identity, eye gaze, expressions of emotion and lip reading to ask how these two disorders uniquely impact upon performance. Participants with WS and autism could be dissociated from those with general developmental delay and from each other primarily on the basis of eye gaze ability. Participants with WS showed strong eye gaze abilities whilst participants with autism had extreme difficulties. Although interpretation of expressions of emotion also showed a difference between groups, autism and WS did not uniquely impact upon the processing of identity or lip reading. The exploration also allowed the consideration of models of face perception; characterised by a typical modular structure in WS but a lack of modularity in autism. The second line of inquiry considered identity processing and firstly asked whether participants were more accurate at matching faces from internal or external features. Participants with WS showed an atypical use of internal features for matching unfamiliar faces, which may be linked to an atypical interaction style and exaggerated interest in unfamiliar people. Participants with autism used the same strategy to match faces of familiar and unfamiliar people and hence familiarity did not impact upon processing style. Subsequent chapters probed feature salience (eyes .v. mouth) and structural encoding. Across paradigms typically developing participants and those with WS showed greater accuracy using the eye than mouth region, a pattern not evident in autism. Regarding structural encoding, individuals with WS showed use of configural cues under the task demands implemented in this thesis, where individuals with autism were only able to interpret featural cues. Previous evidence of similar face processing styles in WS and autism were not supported. Taken together the findings provide further insights into face perception and social functioning in WS and autism. The research used the same participants across paradigms, considered level of functioning on the autistic spectrum and included investigations of WS and autism in the same research programme. Additional to the main experimental studies, pilot data is provided to open a new line of investigation into physiological arousal associated with holding eye contact in WS. Therefore, on the basis of the experiments conducted here, a number of suggestions are made to carry the research forward in future investigations. Throughout the thesis as a whole, comparisons are made between individuals with WS and autism that further our understanding of the links between face processing and social expertise.EThOS - Electronic Theses Online ServiceESRCGBUnited Kingdo

Friendships in children with Williams syndrome : parent and child perspectives

Although children with Williams syndrome (WS) are strongly socially motivated, many have friendship difficulties. The parents of 21 children with WS and 20 of the children themselves participated in a semi-structured interview about the children's friendships. Parents reported that their child had difficulties sustaining friendships and low levels of interaction with peers. Barriers to friendships included difficulties with play and self-regulating behaviour. However, there was within-group variability, with a small number of children reported to have strong friendships. While parents reported friendship challenges, all of the children named at least one friend, and most said that they had never felt excluded by their peers. Future research is needed to determine optimal ways to support children with WS in their friendships

No transfer of arousal from other’s eyes in Williams syndrome

Typically developing humans automatically synchronize their arousal levels, resulting in pupillary contagion, or spontaneous adaptation of pupil size to that of others. This phenomenon emerges in infancy and is believed to facilitate social interaction. Williams syndrome (WS) is a genetic condition characterized by a hyper-social personality and social interaction challenges. Pupillary contagion was examined in individuals with WS (n = 44), age-parallel-matched typically developing children and adults (n = 65), and infants (n = 79). Bayesian statistics were used. As a group, people with WS did not show pupillary contagion (Bayes factors supporting the null: 25–50) whereas control groups did. This suggests a very early emerging atypical developmental trajectory. In WS, higher pupillary contagion was associated with lower autistic symptoms of social communication. Diminished synchronization of arousal may explain why individuals with WS have social challenges, whereas synchronization of arousal is not a necessary correlate of high social motivation

Exploring face perception in disorders of development: evidence from Williams syndrome and autism

Individuals with Williams syndrome (WS) and autism are characterized by different social phenotypes but have been said to show similar atypicalities of face-processing style. Although the structural encoding of faces may be similarly atypical in these two developmental disorders, there are clear differences in overall face skills. The inclusion of both populations in the same study can address how the profile of face skills varies across disorders. The current paper explored the processing of identity, eye-gaze, lip-reading, and expressions of emotion using the same participants across face domains. The tasks had previously been used to make claims of a modular structure to face perception in typical development. Participants with WS (N=15) and autism (N=20) could be dissociated from each other, and from individuals with general developmental delay, in the domains of eye-gaze and expression processing. Individuals with WS were stronger at these skills than individuals with autism. Even if the structural encoding of faces appears similarly atypical in these groups, the overall profile of face skills, as well as the underlying architecture of face perception, varies greatly. The research provides insights into typical and atypical models of face perception in WS and autism

Do faces capture the attention of individuals with Williams syndrome or Autism? Evidence from tracking eye movements

The neuro-developmental disorders of Williams syndrome (WS) and autism can reveal key components of social cognition. Eye‐tracking techniques were applied in two tasks exploring attention to pictures containing faces. Images were i) scrambled pictures containing faces or ii) pictures of scenes with embedded faces. Compared to individuals who were developing typically, participants with WS and autism showed atypicalities of gaze behaviour. Individuals with WS showed prolonged face gaze across tasks, relating to the typical WS social phenotype. Participants with autism exhibited reduced face gaze, linking to a lack of interest in socially relevant information. The findings are interpreted in terms of wider issues regarding socio‐cognition and attention mechanisms